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Workshop 5: Immunology Models: Cell Signalling and Immune Dynamics
(May 10-14, 2004)

Organizers: Denise Kirschner, Jennifer Linderman, and Sergei Pilyugin

The general goal of this workshop is to bring together immune system theorists and experimental immunologists with mathematicians who can become stimulated by this exciting and important area, and who may be able to make an impact by contributing new methods and tools of analysis. First, we will consider how cells of the immune system receive and send signals, i.e., how their surface receptors initiate signaling cascades, and how these cells secrete lymphokines that stimulate other cells of the immune system. Next, we will focus on questions concerning cells of the immune system and how these cells respond and communicate with other cells and antigen. Lastly, we will explore the dynamics of interactions among B cells, T cells, and antigen presenting cells, and the regulation of these populations during an immune response. We will examine events occurring during immune responses, including the formation of spatial structures, such as germinal centers, as well as problems dealing with somatic mutation and affinity maturation. The mathematics employed will involve systems of nonlinear ordinary differential equations, partial differential equations, cellular automata, stochastic processes, and computer simulation.

Schedule

Monday, May 10: Immune Response
9:00-9:15AM Welcome and introduction by Avner Friedman
9:15-9:30AM Topic Introduction by Organizers
9:30-10:15AM Marc Jenkins
10:15-10:35AM Coffee break
10:35-11:20PM Carson Chow
11:20-2:00PM Lunch break
2:00-2:45PM Rustom Antia
2:45-3:05PM Lee Segel
3:05-3:30PM Coffee break
3:30-4:15PM Sergei Pilyugin
5:00-8:00PM Reception and Posters
Tuesday, May 11: Signalling
9:00-9:15AM Topic Introduction by Organizers
9:15-10:00AM Arup Chakraborty
10:00-10:25AM Coffee break
10:25-11:10AM Ravi Iyengar
11:10-11:30AM Coffee break
11:30-12:15PM Raibatak Das
12:15-2:00PM Lunch Break
2:00-2:20PM Benoit Morel
2:20-2:40PM Leslie Loew
2:40-3:10PM Coffee Break
3:10-3:30PM Jason Haugh
3:30-3:50PM Peter Woolf
Contributed talks session
4:00-4:15PM Ruy Ribeiro
4:15-4:30PM Stewart Chang
4:30-4:45PM Dan Coombs
4:45-5:00PM David Klinke
5:00-5:15PM Karen Duca
Wednesday, May 12: Receptor-Ligand Interactions (AM); B-Cells (PM)
9:00-9:15AM Topic Introduction by Organizers
9:15-10:00AM Byron Goldstein
10:00-10:25AM Coffee Break
10:25-11:10AM Jaroslav Stark
11:10-11:30AM Coffee Break
11:30:12:15PM Thomas Kepler
12:15-2:00PM Lunch Break
2:00-2:45PM Phil Hodgkin
2:45-3:05PM Coffee Break
3:05-3:50PM Ramit Mehr
3:50-4:10PM Coffee Break
4:10-4:30PM Lindsay Cowell
4:30-4:50PM Steven Kleinstein
Thursday, May 13: T-Cells
9:00-9:15AM Topic Introduction by Organizers
9:15-10:00AM Gary Huffnagle
10:00-10:30AM Coffee Break
10:30-11:15AM Robin Callard
11:15-11:35AM Ping Ye
11:35-2:00PM Lunch Break
2:00-2:45PM Rob DeBoer
2:45-3:05PM Alan Perelson
3:05-3:35PM Coffee Break
3:35-4:20PM Charles Orosz
4:20-4:40PM Roland Regoes
6:00-9:00PM Buffet Dinner at the Holiday Inn
Friday, May 14: Cell-to-Cell Interactions
9:00-9:15AM Topic Introduction by Organizers
9:15-10:00AM Steven Kunkel
10:00-10:25AM Coffee Break
10:25-11:10AM Penelope Morel
11:10-11:30AM Coffee Break
11:30-12:15PM Zvi Grossman