Workshop 1: Cardiac Electrophysiology and Arrhythmia (September 25-29, 2006)
Organizers: Jim Keener and Rai Winslow
The workshop will concentrate on atrial and ventricular electrophysiology from models of the biophysics of single ion channels to predicting the electrocardiogram recorded at the body's surface. An overarching theme will be how mathematical models can elucidate mechanisms, improve diagnoses, and identify therapeutic targets for cardiac arrhythmias.
Topics will include:
- Molecular Biology of Cardiac Ion Channels and Transporters
- Formulation and Application of Integrative Models of the Cardiac Myoycte
- Tissue and Organ Models
- Arrhythmia Mechanisms
- Excitation-Contraction Coupling
Schedule |
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| Monday, September 25 | |||
| Molecular Biology of Cardiac Ion Channels and Transporters | |||
| 8:45-9:00am | Welcome and Introduction: Avner Friedman and Jim Keener | ||
| 9:00-9:05am | Raimond Winslow: Introduction to Workshop 1 | ||
| 9:05-9:10am | Don Bers: Introduction to Session 1 | ||
| 9:10-10:00am | Colleen Clancy: Cardiac Na Channels Models | ||
| 10:00-10:15am | Coffee Break | ||
| 10:15-11:05am | Randy Rasmusson: Biology and Modeling of Cardiac K Channels | ||
| 11:05-11:20am | Coffee Break | ||
| 11:20-12:10pm | Jon Lederer: Cardiac Ca Dynamics | ||
| 12:10-12:40pm | Catteral, Clancy, and Rasmusson: Panel Discussion - Channels and Models | ||
| 12:40-2:30pm | Lunch Break | ||
| 2:30-3:20pm | Don Bers: Cardiac L-type Ca Channels, RyR2s and SERCA2a | ||
| 3:20-3:35pm | Coffee Break | ||
| 3:35-4:25pm | Don Bers: Na-Ca Exchange in Cardiac Myocytes | ||
| 4:25-4:55pm | Panel Discussion - Cardiac Ca-Handling Proteins | ||
| 5:00-8:00pm | Reception held in Math Tower, Room 724 | ||
| Tuesday, September 26 | |||
| Formulation and Application of Integrative Models of the Cardiac Myocyte | |||
| 8:30-8:35am | Yoram Rudy: Introduction to Session 2 | ||
| 8:35-9:25am | Yoram Rudy: Ventricular Myocyte Model, Channelopathies and Arrhythmia | ||
| 9:25-9:40am | Coffee Break | ||
| 9:40-10:30am | Raimond Winslow: Calcium-Induced Calcium-Release: Insights From Studies of Heart Failure | ||
| 10:30-10:45am | Coffee Break | ||
| 10:45-11:35am | Martin Falcke: Stochastic models of complex molecules | ||
| 11:35-1:00pm | Lunch Break | ||
| 1:00-1:30pm | Panel Discussion - Future Directions for Integrative Cell Modeling | ||
| 1:30-1.45pm | Coffee Break | ||
| 1:45-1:50pm | Peter Hunter: Introduction to Session | ||
| 1:50-2:40pm | Peter Hunter: Tissue and organ level cardiac electrophysiological modelling | ||
| 2:40-2:55pm | Coffee Break | ||
| 2:55-3:45pm | Michael Miller: Computational Anatomy and the Infinite Dimensional Diffeomorphisms | ||
| 3:45-4:00pm | Coffee Break | ||
| 4:00-4:30pm | Hunter and Miller: Panel Discussion - Measurement, Analysis and Modeling of Cardiac Anatomy | ||
| 6:30pm | Public Lecture Series Carlos Castillo-Chavez: Emergent Disease and the Challenges of Globalization Location: Fawcett Center Auditorium, 2400 Olentangy River Road |
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| Wednesday, September 27 | |||
| Tissue and Organ Models | |||
| 8:30-9:20am | Sasha Panfilov: Modeling Electrical Conduction in the Cardiac Ventricles | ||
| 9:20-9:35am | Coffee Break | ||
| 9:35-10:25am | Natalia Trayanova: Bidomain Models: Inducing and Terminating VF | ||
| 10:25-10:40am | Coffee Break | ||
| 10:40-11:30am | Candido Cabo:Cellular Mechanisms of Stability of Reentrant Tachycardias in Infarcted Hearts | ||
| 11:30-11:45am | Coffee Break | ||
| 11:45-12:35pm | Craig Henriquez: Modeling the Arrhythmogenic Substrate: Incorporating Heterogeneity at the Microscale in Cardiac Tissue Models | ||
| 12:35-1:00pm | Panel Discussion - Future Directions for Large-Scale Electrical Modeling | ||
| 1:00-2:30pm | Lunch Break | ||
| 2:30-2:35pm | David Rosenbaum: Introduction to Session | ||
| 2:35-3:25pm | Michael Guevara: Synchronization rhythms in the heart | ||
| 3:25-3:40pm | Coffee Break | ||
| 3:40-4:30pm | Guy Salama: Wavelets, Wavebreaks and Ventricular Fibrillation | ||
| 4:30-5:00pm | Panel Discussion - | ||
| Thursday, September 28 | |||
| Arrhythmia Mechanisms | |||
| 9:00-9:50am | Mario Delmar: Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC): A disease of the intercalated disc | ||
| 9:50-10:05am | Coffee Break | ||
| 10:05-10:55am | David Rosenbaum: Alternans | ||
| 10:55-11:10am | Coffee Break | ||
| 11:10-12:00pm | Igor Efimov: Reentrant Arrhythmias | ||
| 12:00-1:30pm | Lunch Break | ||
| 1:30-2:20pm | Kenneth Laurita: Arrhythmia Mechanisms: Myocardial Infarction | ||
| 2:20-2:50pm | Panel Discussion: Arrhythmia Mechanisms | ||
| 2:50-3:05pm | Coffee Break | ||
| 3:05-3:10pm | Saleet Jafri: Introduction to Session | ||
| 3:10-4:00pm | Sandor Gyorke: Biology of RyR2 | ||
| 4:00-4:15pm | Coffee Break | ||
| 4:15-5:05pm | Clara Franzini-Armstrong: Structure of the Dyad | ||
| 6:00pm | Dinner at the Holiday Inn on the Lane | ||
| Friday, September 29 | |||
| Excitation-Contraction Coupling | |||
| 9:00-9:50am | Saleet Jafri: Biology and Computational Models of Ca Sparks | ||
| 9:50-10:05am | Coffee Break | ||
| 10:05-10:55am | Greg Smith: A probability density approach to modeling local calcium signaling and stochastic functional unit activity in cardiac myocytes | ||
| 10:55-11:25am | Panel Discussion - Ec Coupling | ||
| 11:25am | Wrap-up | ||
