Mathematical Challenges in
Developmental Biology 2008-2009
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Workshop 2: Cardiac Mechanics and Remodeling (October 2-6, 2006)

Organizers: Jim Keener and Andrew McCulloch

The workshop will address the mechanical function of the heart from models of the biophysics and biochemistry of molecular motors to predicting the three-dimensional mechanical performance of the whole heart. The theme threading through this workshop will be how mathematical models can improve the diagnosis and treatment of cardiac mechanical dysfunction during disease, especially congestive heart failure, and elucidate the mechanisms by which mechanical factors can regulate cardiac remodeling in vivo.

Topics will include:

  • Metabolic and Neurohumoral Regulation of Excitation and Contraction
  • Cardiac Muscle Contraction
  • Cardiac Constitutive Models
  • Modeling Cardiac Mechanics
  • The Intact Heart

Schedule
Monday, October 2: Metabolic and Neurohumoral Regulation of Excitation and Contraction
8:30-9:00am Coffee and Registration
9:00-9:15am Welcome and Introduction: Avner Friedman, Jim Keener, and Andrew McCulloch
9:15-10:00am Brian O'Rourke: Cardiac Mitochondrial Function and Energetics
10:00-10:15am Coffee Break
10:15-11:00am Miguel Aon: The heart cell viewed from the mitochondrial network: Scaling mitochondrial dynamics to arrhythmias
11:00-11:15am Coffee Break
11:15-12:00pm Anushka Michailova: Adenosine Nucleotides and Lewis Acids Regulate Cardiac Excitation-Metabolic Coupling
12:00-1:30pm Lunch Break
1:30-2:15pm Daniel Beard: Computational Modeling of Oxygen Transport and Cellular Energetics Explains Observations on In Vivo Cardiac Oxygen Consumption and Energy Metabolites
2:15-2:30pm Coffee Break
2:30-3:15pm R. John Solaro: Regulation of Cardiac Dynamics at the Level of Sarcomeric Proteins
3:15-3:30pm Coffee Break
3:30-4:15pm Jeffrey Saucerman: Beta-Adrenergic signaling and regulation of the heart
5:00-7:00pm Reception held in Math Tower, Room 724
Tuesday, October 3: Cardiac Muscle Contraction
9:00-9:45am Pieter de Tombe: Myofilament Length Dependent Activation and the Frank-Starling Law of the Heart
9:45-10:00am Coffee Break
10:00-10:45am J. Jeremy Rice: An ODE-based myofilament model approximates spatially-dependent cooperative mechanisms and crossbridge cycling
10:45-11:00am Coffee Break
11:00-11:45am P. Bryant Chase: Crossbridge Mechanics
11:45-1:15pm Lunch Break
1:15-2:00pm Paul Janssen: Frequency dependence of cardiac muscle contraction and relaxation
2:00-2:15pm Coffee Break
2:15-3:00pm Henk ter Keurs: Arrhythmogenic spontaneous sarcomere activity in CHF
3:00-3:15pm Coffee Break
3:15-4:00pm Amir Landesberg: Crissbridge Cycle
6:30pm Public Lecture Series: Jim Keener: Heart Attacks can give you Mathematics
Wednesday, October 4: Cardiac Constitutive Models
9:00-9:45am Kevin Costa: Cardiac Cell Mechanics and the Healthy and Failing Heart
9:45-10:15am Coffee Break
10:15-11:00am Michael Sacks: Biomechanics of native and engineered heart valve tissues
11:00-1:00pm Lunch Break
1:00-1:45pm Jeffrey Omens: Cardiac Mechanotransduction
1:45-2:00pm Coffee Break
2:00-2:45pm John Criscione: Mechanical Models of Myocardium: Current Failures and Future Directions
2:45-3:00pm Coffee Break
3:00-3:45pm Jeffrey Holmes: The Mechanics of Healing Myocardial Infarcts and Tissue-Engineered Analogs
Thursday, October 5: Modeling Cardiac Mechanics
9:00-9:45am Larry Taber: Biomechanics of Cardiovascular Development and Functional Adaptation
9:45-10:15am Coffee Break
10:15-11:00am Theo Arts: Using rules for adaptation to mechanical load in patient-specific modeling of heart and circulation
11:00-1:00pm Lunch Break
1:00-1:45pm Natalia Trayanova: Mechanoelectric Feedback in the Intact Heart
1:45-2:00pm Coffee Break
2:00-2:45pm Julius Guccione: Modeling Cardiac Mechanics: Surgical Interventions
2:45-3:00pm Coffee Break
3:00-4:00pm Panel Discussion
6:00-8:00pm Dinner at the Holiday Inn on the Lane
Friday, October 6: The Intact Heart
9:00-9:45am Alistair Young: Image-derived Cardiac Models
9:45-10:00am Coffee Break
10:00-10:45am Igor Efimov: Optical Mapping of Cardiac Electrical Acitivity
10:45-11:00am Coffee Break
11:00-11:45pm Nicolas Smith: Modeling Coronary Perfusion