Workshop 4: Blood Flow in the Microcirculation: Function, Regulation and Adaptation
(January 22-26, 2007)
The function of the systemic circulatory system is to distribute
and remove materials and heat as needed throughout the body. Transport
is achieved by convection in the blood and diffusive exchange with
surrounding tissue. Because diffusion is effective only over short
distances, blood must be brought close to every point in the tissue.
To make this possible, the peripheral circulation consists of a
highly branched system of blood vessels, containing more than 109
segments, ranging in diameter from about 1 cm down to a few µm.
The vessels of diameter about 100 µm or less are referred
to as the microcirculation.
This workshop will focus on three areas:
- blood flow and mass transport in the microcirculation;
- short-term regulation of blood flow, including vascular smooth
muscle behavior;
- structural adaptation of blood vessels, including angiogenesis.
Mathematical and computational approaches can make important contributions
in all these areas. Continuum and multiphase models can be applied
to study blood flow. Simulations of mass and heat transport also
typically require solution of partial differential equations. Consideration
of network properties is critical to understanding short and long-term
control of blood flow. The network can be regarded as a dynamic
system in which the properties of each segment (diameter, etc.)
evolve with time. Simulations of angiogenesis can use a variety
of approaches, including deterministic and stochastic models and
cellular automata.
Schedule |
Monday, January 22
Structure and function of microcirculation |
| 9:00-9:15am |
Welcome and Introduction from Avner Friedman |
| 9:15-10:00am |
Tim Secomb: Microcirculation and mathematical modeling: A brief history |
| 10:00-10:30am |
Coffee break |
| 10:30-11:30am |
Erik L Ritman: Measuring intact Vascular Trees by 3D Imaging Methods |
| 11:30-1:30am |
Lunch break |
| 1:30-2:30pm |
Ghassan Kassab: Scaling laws of vascular trees |
| 2:30-3:00pm |
Coffee break |
| 3:00-4:00pm |
James Bassingthwaighte: Transport and Exchange in the Microcirculation: Interactions amongst RBC, Endothelial Cells and Cardiomyocytes |
| 4:00-5:00pm |
Short talks on posters |
| 5:00-7:00pm |
Reception and Poster Session |
Tuesday, January 23
Mass transport in microcirculation |
| 9:00-10:00am |
Roland Pittman: An Overview of Oxygen Transport in the Microcirculation: Experimental Considerations |
| 10:00-10:30am |
Coffee break |
| 10:30-11:30am |
Daniel Goldman: Computational modeling of blood-tissue oxygen transport |
| 11:30-1:30pm |
Lunch break |
| 1:30-2:30pm |
Nikolaos Tsoukias: Integrative Models of Nitric Oxide Biotransport and Calcium Dynamics in the Microcirculation |
| 2:30-3:00pm |
Coffee break |
| 3:00-4:00pm |
Short Talks on Posters |
| 4:00-5:00pm |
Poster Session: John B. Geddes, Fan Wu, Luoding Zhu, Amina A. Qutub (2 posters) , Karin Leiderman, Ryon Bateman and Mahendra Kavdia |
| 6:30pm |
James Hoying: Public Lecure - Tissue Engineering and Repair: A Vascular Problem |
Wednesday, January 24
Regulation of blood flow |
| 9:00-10:00am |
Jefferson Frisbee: Overview of blood flow regulation |
| 10:00-10:30am |
Coffee break |
| 10:30-11:30am |
Timothy Secomb: Models for microvascular regulation of blood flow |
| 11:30-1:30pm |
Lunch break |
| 1:30-2:30pm |
Mette Sofie Olufsen: Dynamics of blood flow regulation |
| 2:30-3:00pm |
Coffee break |
| 3:00-4:00pm |
Short Talks on Posters |
| 4:00-5:00pm |
Poster Session: Julia Arciero, Murad Banaji, Trevor R. Cardinal, Jin Yang, Nicanor I. Moldovan (2 posters) , Kejing Chen (2 posters), Tuhin K Roy, Brian Carlson and Laura Ellwein |
Thursday, January 25
Structural adaptation and angiogenesis |
| 9:00-10:00am |
James Hoying: Angiogenesis, vascular maturation, and microvessel network remodeling |
| 10:00-10:30am |
Coffee break |
| 10:30-11:30am |
Shayn Peirce-Cottler: Multicellular Simulations of Microvascular Patterning |
| 11:30-1:30pm |
Lunch break |
| 1:30-2:30pm |
Axel Pries: Structural vascular adaptation in the microcirculation |
| 2:30-3:00pm |
Coffee break |
| 3:00-4:00pm |
Short Talks on Posters |
| 4:00-5:00pm |
Poster Session: Annemiek JM Cornelissen, Gabriel Gruionu, Jens Christian Brings Jacobsen, Jay Walton, and Feilim Mac Gabhann (2 posters), and Nicolas Smith |
| 6:00-7:00pm |
Drinks at the Holiday Inn |
| 7:00-9:00pm |
Dinner at the Holiday Inn |
Friday, January 26
Cellular processes and microcirculation |
| 9:00-10:00am |
Aleksander Popel: Systems Biology of Angiogenesis: From Molecules to Therapy |
| 10:00-10:30am |
Coffee break |
| 10:30-11:30am |
Daniel Beard: Integrating cell metabolism, flow, and tissue function |
