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Workshop 7: Insulin Secretion, Insulin Action, and Type 2 Diabetes (May 21-24, 2007)

Organizers: Richard Bertram, Arthur Sherman, and Les Satin

The current rise in the rates of diabetes 2 and obesity, combined with the rapid expansion of knowledge of basic biology, present great opportunities for mathematical modeling. In some areas, mathematics has already made important contributions, particularly understanding the genesis and regulation of the oscillations of electrical activity and calcium that drive insulin secretion. There has also been significant modeling work on insulin action and whole-body metabolism. This workshop will expose modelers to new problem areas and showcase the areas where progress has already been made to experimentalists.

The topics of the workshop will include:

  • Mechanisms of insulin secretion
  • Insulin action
  • Mechanisms of disease
  • Hypothalamic regulation of food intake and energy expenditure
  • Glucose sensing outside the beta-cell
  • Exemplary models at the gene and molecular level

Schedule
Monday, May 21
8:45-9:00am Welcome and introduction with Avner Friedman
Imaging Islets
9:00-9:30am Manami Hara: Imaging Pancreatic Beta-Cells
9:30-10:00am Richard Benninger: Imaging and Modeling of Gap Junction Connectivity in the Islets of Langerhans
10:00-10:30am Coffee break
Exocytosis
10:30-11:00am Robert Chow: Imaging glucose-stimulated pulsatile bursts of insulin exocytosis in single human pancreatic beta cells
11:00-11:30am Debbie Thurmond: Novel mechanisms for regulation of second-phase insulin secretion involving Cdc42, Syntaxin 4 and the actin cytoskeleton
11:30-1:30pm Lunch
Signaling to the Nucleus and ER
1:30-2:00pm James Johnson: Intracellular calcium stores in beta-cell function and survival
2:00-2:30pm Anders Tengholm: Cyclic AMP oscillations in ß-cells
2:30-3:00pm Coffee break
3:00-4:15pm Poster advertisements (5-minute overviews)
4:15-5:30pm Poster session: Morten Gram Pedersen, Brad Peercy, Mike Roper, and K.V. Venkatesh
6:00-8:00pm Reception in MW 724
Tuesday, May 22
Calcium, Ion Channels, and Insulin Secretion
9:00-9:30am Jean-Claude Henquin: Insulin secretion with and without KATP channels in ß-cells
9:30-10:00am Colin Nichols: Metabolism-excitation coupling: Cellular lessons from animal models
10:00-10:30am Coffee break
Electrical and Metabolic Oscillations
10:30-11:00am Leslie Satin: Islet oscillations. Synchronization and experimental tests of the dual oscillator model
11:00-11:30am Richard Bertram: Metabolic and Electrical Oscillations: Partners in Controlling Rhythmic Islet Activity
11:30-1:30pm Lunch
Metabolism
1:30-2:00pm Gary Cline: 13C-Isotopomer analysis of anaplerosis and pyruvate cycling in nutrient-stimulated insulin secretion
2:00-2:30pm Keith Tornheim: Metabolic oscillations and insulin secretion
2:30-3:00pm Coffee break
3:00-4:15pm Poster advertisements (5-minute overviews)
4:15-5:30pm Poster session: Pranay Goel, Les Satin, Artie Sherman, Christine Hallgreen, and James Herrington
Wednesday, May 23
Plasma Insulin Oscillations
9:00-9:30am Orian Shirihai: Life Cycle of Mitochondria in the living and in the digitized ß-Cell: Birth, Love and Death at subcellular levels
9:30-10:00am Morten Gram Pedersen: Entrainment and synchrony of insulin pulses
10:00-10:30am Coffee break
Whole-Body Glucose, Insulin Models, Assessing Insulin Action, and Beta-Cell Function
10:30-11:00am Andrea Mari: Beta-cell function modeling for widely applicable clinical tests: review of recent experience
11:00-11:30am Chiara Dalla Man: Role of Models to Measure Insulin Action
11:30-1:30pm Lunch
Assessing Beta-Cell Mass and Function
1:30-2:00pm Jake Kushner: Beta Cell Replication Dyanamics
2:00-2:30pm Gianna Toffolo: Minimal model assessment of beta cell function, hepatic insulin extraction and their interplay with insulin action in humans
2:30-3:00pm Coffee break
3:00-4:15pm Poster advertisements (5-minute overviews)
4:15-5:30pm Poster session: Rachel Altura, Junghyo Jo, Jiaxu Li, and Masayoshi Seike
7:00pm Dinner at the Holiday Inn on the Lane
Thursday, May 24
Insulin Signaling: Islets, Vasculature
9:00-9:30am Rohit Kulkarni: Insulin signaling and beta cell proliferation
9:30-10:00am Ranganath Muniyappa: Insulin Action in Vascular Endothelium
10:00-10:30am Coffee break
Insulin Signaling: Fat, Brain
10:30-11:00am Vipul Periwal: Quantitative Estimation of Sensitivity of Lipolysis to Insulin
11:00-11:30am Vanessa Routh: Glucose-insulin interaction in the regulation of hypothalamic glucose sensing neurons
11:30-1:30pm Lunch
Models of Signaling Pathways
1:30-2:00pm Jonathan Fitzgerald: Understanding IGF signaling dynamics through computational modeling
2:00-2:30pm Michael Blinov: Rule-based Modeling of Signal Transduction
2:30-3:00pm Coffee break
3:00-4:30pm Panel discussion