The current rise in the rates of diabetes 2 and obesity, combined
with the rapid expansion of knowledge of basic biology, present
great opportunities for mathematical modeling. In some areas, mathematics
has already made important contributions, particularly understanding
the genesis and regulation of the oscillations of electrical activity
and calcium that drive insulin secretion. There has also been significant
modeling work on insulin action and whole-body metabolism. This
workshop will expose modelers to new problem areas and showcase
the areas where progress has already been made to experimentalists.
Schedule |
| Monday, May 21 |
| 8:45-9:00am |
Welcome and introduction with Avner Friedman |
| Imaging Islets |
| 9:00-9:30am |
Manami Hara: Imaging Pancreatic Beta-Cells |
| 9:30-10:00am |
Richard Benninger: Imaging and Modeling of Gap Junction Connectivity in the Islets of Langerhans |
| 10:00-10:30am |
Coffee break |
| Exocytosis |
| 10:30-11:00am |
Robert Chow: Imaging glucose-stimulated pulsatile bursts of insulin exocytosis in single human pancreatic beta cells |
| 11:00-11:30am |
Debbie Thurmond: Novel mechanisms for regulation of second-phase insulin secretion involving Cdc42, Syntaxin 4 and the actin cytoskeleton |
| 11:30-1:30pm |
Lunch |
| Signaling to the Nucleus and ER |
| 1:30-2:00pm |
James Johnson: Intracellular calcium stores in beta-cell function and survival |
| 2:00-2:30pm |
Anders Tengholm: Cyclic AMP oscillations in ß-cells |
| 2:30-3:00pm |
Coffee break |
| 3:00-4:15pm |
Poster advertisements (5-minute overviews) |
| 4:15-5:30pm |
Poster session: Morten Gram Pedersen, Brad Peercy, Mike Roper, and K.V. Venkatesh |
| 6:00-8:00pm |
Reception in MW 724 |
Tuesday, May 22
Calcium, Ion Channels, and Insulin Secretion |
| 9:00-9:30am |
Jean-Claude Henquin: Insulin secretion with and without KATP channels in ß-cells |
| 9:30-10:00am |
Colin Nichols: Metabolism-excitation coupling: Cellular lessons from animal models |
| 10:00-10:30am |
Coffee break |
| Electrical and Metabolic Oscillations |
| 10:30-11:00am |
Leslie Satin: Islet oscillations. Synchronization and experimental tests of the dual oscillator model |
| 11:00-11:30am |
Richard Bertram: Metabolic and Electrical Oscillations: Partners in Controlling
Rhythmic Islet Activity |
| 11:30-1:30pm |
Lunch |
| Metabolism |
| 1:30-2:00pm |
Gary Cline: 13C-Isotopomer analysis of anaplerosis and pyruvate cycling in nutrient-stimulated insulin secretion |
| 2:00-2:30pm |
Keith Tornheim: Metabolic oscillations and insulin secretion |
| 2:30-3:00pm |
Coffee break |
| 3:00-4:15pm |
Poster advertisements (5-minute overviews) |
| 4:15-5:30pm |
Poster session: Pranay Goel, Les Satin, Artie Sherman, Christine Hallgreen, and James Herrington |
Wednesday, May 23
Plasma Insulin Oscillations |
| 9:00-9:30am |
Orian Shirihai: Life Cycle of Mitochondria in the living and in the digitized ß-Cell: Birth, Love and Death at subcellular levels |
| 9:30-10:00am |
Morten Gram Pedersen: Entrainment and synchrony of insulin pulses |
| 10:00-10:30am |
Coffee break |
| Whole-Body Glucose, Insulin Models, Assessing Insulin Action, and Beta-Cell Function |
| 10:30-11:00am |
Andrea Mari: Beta-cell function modeling for widely applicable clinical tests: review of recent experience |
| 11:00-11:30am |
Chiara Dalla Man: Role of Models to Measure Insulin Action |
| 11:30-1:30pm |
Lunch |
| Assessing Beta-Cell Mass and Function |
| 1:30-2:00pm |
Jake Kushner: Beta Cell Replication Dyanamics |
| 2:00-2:30pm |
Gianna Toffolo: Minimal model assessment of beta cell function, hepatic insulin extraction and their interplay with insulin action in humans |
| 2:30-3:00pm |
Coffee break |
| 3:00-4:15pm |
Poster advertisements (5-minute overviews) |
| 4:15-5:30pm |
Poster session: Rachel Altura, Junghyo Jo, Jiaxu Li, and Masayoshi Seike |
| 7:00pm |
Dinner at the Holiday Inn on the Lane |
Thursday, May 24
Insulin Signaling: Islets, Vasculature |
| 9:00-9:30am |
Rohit Kulkarni: Insulin signaling and beta cell proliferation |
| 9:30-10:00am |
Ranganath Muniyappa: Insulin Action in Vascular Endothelium |
| 10:00-10:30am |
Coffee break |
| Insulin Signaling: Fat, Brain |
| 10:30-11:00am |
Vipul Periwal: Quantitative Estimation of Sensitivity of Lipolysis to Insulin |
| 11:00-11:30am |
Vanessa Routh: Glucose-insulin interaction in the regulation of hypothalamic glucose sensing neurons |
| 11:30-1:30pm |
Lunch |
| Models of Signaling Pathways |
| 1:30-2:00pm |
Jonathan Fitzgerald: Understanding IGF signaling dynamics through computational modeling |
| 2:00-2:30pm |
Michael Blinov: Rule-based Modeling of Signal Transduction |
| 2:30-3:00pm |
Coffee break |
| 3:00-4:30pm |
Panel discussion |
