CTW: Mathematical and Computational Challenges in Cilia- and Flagella-Induced Fluid Dynamics (October 15-18, 2012)
Organizers: Kenny Breuer, Greg Forest, Anita Layton, Matthias Salathe, and Peter Satir
Cilia and flagella are ubiquitous in cell biology, acting either in a coordinated fashion to move surrounding fluid such as in lung airways, or as a propeller for cell locomotion such as on sperm or eukaryotic microorganisms, or as a sensory immotile but flexible antenna such as the primary cilia in essentially every cell in vertebrates and many vertebrate and invertebrate sense organs. The fluid dynamics induced by cilia and flagella, the mechanisms of coordination of motile cilia and flagella, and the fluid dynamic feedback to intra-ciliary and intra-flagellar transport and signaling, are essential to biology. The purpose of this workshop is to convene experts in biology, physics, mathematical modeling, and scientific computation to collectively assess progress and identify challenges to be undertaken in cilia- and flagella-induced fluid dynamics.
A list of outstanding challenges and computational strategies will be highlighted through lectures and subsequent discussions and open forums: (i) methods to compute and resolve the fluid-structure interaction of a cilium or flagellum, in either a viscous or viscoelastic fluid; (ii) stochastic (based on molecular motors) versus deterministic coarse-grained models of cilia and flagella beat cycles; (iii) the coordination mechanisms of cilia and flagella through the intervening fluid and/or the cells they emanate from; (iv) fluid mechanical sensing by the cilium or flagellum and the feedback response; (v) fundamental questions of optimization and efficiency (tuning of ciliary or flagellar motion or tuning of fluid properties to optimize motility or fluid transport; (vi) experimental and engineering approaches to support and challenge new modeling approaches. These challenges require assessment of current formulations and analysis of the governing equations for existing models, attention to accuracy, stiffness, time-stepping, adaptive mesh refinement, parallel implementation, and computing architectures.
Accepted Speakers
- Martina Brueckner, Biological and Biomedical Sciences, Yale University
- Ricardo Cortez, Mathematics, Tulane University
- Robert Dillon, Mathematics, Washington State University
- Zvonimir Dogic, Physics, Brandeis University
- Tim Elston, Pharmacology, UNC School of Medicine
- Lisa Fauci, Mathematics, Tulane University
- Marc Fermigier, Laboratoire PMMH, ESPCI-ParisTech
- Ambarish Ghosh, Electrical Communication Engineering and Physics, Indian Institute of Science
- Ramin Golestanian, Physics, University of Oxford
- Kent Hill, MIMG, UCLA
- Steve King, Molecular Microbial and Structural Biology, University of Connecticut Health Center
- Karl Lechtreck, Cellular Biology, University Georgia
- Karin Leiderman, Mathematics, University of California at Merced
- Sorin Mitran, Mathematics, University of North Carolina at Chapel Hill
- Chris O'Callaghan, Infection, Immunity, and Inflammation, University of Leicester
- Sarah Olson, Mathematical Sciences, Worcester Polytechnic Institute
- Helle Praetorius, Department of Physiology and Biophysics, Aarhus University, Denmark
- Win Sale, Department of Cell Biology, Emory University
- Michael Shelley, Mathematics, Courant Institute of Mathematical Science, New York University
- Saverio Spagnolie, Mathematics, Wisconsin University
- Anna-Karin Tornberg, Mathematics, Courant Inst., NYU
