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2004 Summer Graduate Program

This year the program will focus on Cell Processes. The program leader is Professor James Sneyd. After an introductory tutorial and discussion in the first two days, the participants will be divided into teams of five, with each team being led by an MBI postdoc. Teams will work on one project for the first two and a half weeks, and there will be a miniconference in the final two days.

During the three-week period there will also be several general talks on cell cycle and proliferation by active researchers and visits to bioscience labs.

Week 1

Monday, August 2
9:00-9:05am Welcome (Avner Friedman)
9:05-10:05am James Sneyd: Enzyme kinetics - PPT
10:05-10:30am Break
10:30-11:30am James Sneyd: How cells control their volume - PPT
11:30-2:00pm Lunch
2:00-3:00pm Martin Wechselberger: Introduction to Dynamical Systems: Phase analysis and bifurcation
3:00-4:00pm Pranay Goel: Introduction to XPP
Tuesday, August 3
9:00-10:00am James Sneyd: Calcium physiology - PPT
10:00-10:30am Break
10:30-11:30am James Sneyd: Cardiac electrical physiology - PPT
11:30-1:30pm Lunch
1:30-2:00pm Martin Wechselberger: Introduction to Dynamical Systems (continued)
2:00-3:00pm Pranay Goel: XPP (continued)
3:00-3:30pm Break
3:30-5:30pm Project leaders describe their projects.
Wednesday, August 4
9:00-10:00am Participants write their preferred projects
10:00am Teams are selected and begin work, guided by their project leaders
Thursday, August 5
9:00-10:00am Gustavo Leone: Cellular Differentiation and Cancer - PPT1
Friday, August 6
9:00-10:00am Gustavo Leone: Cellular Differentiation and Cancer - PPT2

Week 2

Tuesday, August 10
1:00-2:00pm Andrea Doseff: Apoptosis I
Wednesday, August 11
1:00-2:00pm Andrea Doseff: Apoptosis II
2:00-4:00pm Andrea Doseff: Lab
Thursday, August 12
1:00-2:00pm Berl Oakley: Gamma-tubulin functions in microtubule nucleation and cell cycle regulation
2:00pm Berl Oakley: Lab
Friday, August 13
4:00pm Gustavo Leone: Lab

Thursday, August 19; 12:30pm - 5:00pm

Project 1: Calcium and Heart Failure
Project Leader: Pranay Goel

Construct a model for a calcium transient in a normal ventricular myocyte, and in heart failure cells that explain the differences in the calcium transients. How does your model cope with calcium overload?

Project 2: Synaptic Plasticity
Project leader: Alla Borisyuk
Presentation: PPT

Synaptic transmission and synaptic plasticity.

Project 3: Cell Cycle and Apoptosis
Project leader: Gheorghe Craciun
Presentation: PPT

Construct a model that couples cell cycle and apoptosis.

Friday, August 20; 9:00am - 12:00pm

Project 4: Olfaction
Project leader: Daniel Dougherty

Construct a model of a signal transduction and adaptation in odoreceptors.

Project 5: Calcium Oscillations
Project leader: Martin Wechselberger

Design a realistic experimental protocol that will determine the role of [IP3] in Ca2+ oscillations in pancreatic acinar cells.