 |
 |
Office: JE 377
Phone: (614) 688-3198
Email: mdjordjevic@mbi.osu.edu
Mentors:
Curriculum Vitae: PDF
Research Description: PDF
Research Area
My research is broadly in the areas of quantitative systems biology, biophysics, and bioinformatics and includes both quantitative modeling of biological systems and developing novel methods for data analysis. Another goal of my work is to use physical modeling to help in developing optimal experimental design. Problems that I work on are mostly related with different aspects of gene expression and its regulation, and recent interests include: i) modeling transcription initiation in bacteria ii) understanding design of simple genetic circuits iii) understanding how proteins recognize functional binding sites in genome. A more detailed description of my research is given in the link Research Description above.
Selected publications:
- Djordjevic M and Bundschuh R, Open complex formation by bacterial RNA polymerase - a quantitative model, Biophysical Journal, in press (2008).
- Bogdanova E, Djordjevic M, Papapanagiotou I, Heyduk T, Kneale G and Severinov K, Transcription regulation of the type II restriction-modification system AhdI, Nuclear Acids Research, in press (2008).
- Djordjevic M, SELEX experiments: novel prospects applications and data analysis for inferring regulatory pathways, Biomolecular Engineering 24(2):179, 2007 (invited review paper).
- Sevostyanova A, Djordjevic M, Kuznedelov K, Naryshkina T, Gelfand M, Severinov K and Minakhin L, Temporal regulation of viral transcription during development of Thermus thermophilus bacteriophage phiYS40, Journal of Molecular Biology 366(2):420, 2007.
-
Djordjevic M, Semenova E, Shraiman B and Severinov K, Quantitative analysis of transcription strategy by a virulent bacteriophage, Virology, 354(2):240, 2006.
- Djordjevic M, Sengupta A M, Quantitative modeling and data analysis of SELEX experiments, Physical Biology 3:13, 2006.
- Semenova E, Djordjevic M, Shraiman B and Severinov K, The tale of two RNA polymerases: transcription profiling and gene expression strategy of bacteriophage Xp10, Molecular Microbiology 55:764, 2005.
- Djordjevic M, Sengupta A M and Shraiman B, A biophysical approach to transcription factor binding site discovery, Genome Research 13(11):2381, 2003.
- Sengupta A M, Djordjevic M, Shraiman B, Specificity and robustness in transcription control networks, Proceedings of the National Academy of Science 99:2072, 2002. |
